Desjardins was acquired by the Flyers from the Montreal Canadiens on February 9, 1995. Desjardins became one of the highest-scoring defensemen in Flyers history, recording 396 points (93 G, 303 A) over 738 career games to rank second in franchise history among blueliners in goals, assists and points, behind only Mark Howe.
Two of his best seasons came in 1998-99 and 1999-2000, the first of which saw him record 51 points (15 G, 36 A) in just 68 games. The following year, Desjardins posted 55 points (14 G, 41 A) in 80 games. He was named a second-team postseason NHL All-Star in both seasons and finished in the top five in Norris Trophy voting in both of those years.
Desjardins was a seven-time Barry Ashbee Award winner as the Flyers’ best defenseman, which is a franchise high, and was a three time NHL All-Star – once with Montreal in 1992 and twice with the Flyers, in 1996 and 2000. He won a gold medal with Team Canada at the 1998 Winter Olympics.